diff --git a/board/pyro/board.h b/board/pyro/board.h
index 2566830e2f..3aa7d6002a 100644
--- a/board/pyro/board.h
+++ b/board/pyro/board.h
@@ -129,6 +129,8 @@
 #undef   CONFIG_EXTPOWER_DEBOUNCE_MS
 #define  CONFIG_EXTPOWER_DEBOUNCE_MS 1000
 #define CONFIG_FPU
+/* Region sizes are not a power of 2 so we can't use MPU */
+#undef  CONFIG_MPU
 #define CONFIG_HOSTCMD_FLASH_SPI_INFO
 #define CONFIG_I2C
 #define CONFIG_I2C_MASTER